Rabbit Secondary Antibodies
ABclonal Technology SIRT7 Rabbit mAb
This gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes The functions of human sirtuins have not yet been determined however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity The protein encoded by this gene is included in class IV of the sirtuin family
ABclonal Technology UFM1 Rabbit mAb
UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1 MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M MIM 603173) (Komatsu et al 2004 [PubMed 15071506])
ABclonal Technology MUC16/CA125 Rabbit mAb
This gene encodes a membrane-tethered mucin protein involved in forming a protective mucous barrier on epithelial surfaces The protein has an extracellular domain at its amino terminus a large tandem repeat region rich in serines threonines and prolines and a transmembrane domain with a short cytoplasmic tail The repeat region includes SEA (Sea urchin sperm protein Enterokinase and Agrin) leucine-rich and ankyrin repeats forming the ectodomain A potential cleavage site is near an SEA module This protein is believed to protect epithelial cells from pathogens It is used as a cancer marker with higher expression linked to poorer outcomes
ABclonal Technology NKX3.1 Rabbit mAb
This gene encodes a homeobox-containing transcription factor This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue Aberrant expression of this gene is associated with prostate tumor progression Alternate splicing results in multiple transcript variants of this gene
ABclonal Technology CD26/DPP4 Rabbit mAb
The DPP4 gene encodes dipeptidyl peptidase 4 which is identical to adenosine deaminase complexing protein-2 and to the T-cell activation antigen CD26 It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism as well as in immune regulation This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) and protein modeling suggests that it may play a similar role with SARS-CoV-2 the virus responsible for COVID-19
ABclonal Technology TMEM43 Rabbit mAb
This gene belongs to the TMEM43 family Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5) also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5) Arrhythmogenic right ventricular dysplasia is an inherited disorder often involving both ventricles and is characterized by ventricular tachycardia heart failure sudden cardiac death and fibrofatty replacement of cardiomyocytes This gene contains a response element for PPAR gamma (an adipogenic transcription factor) which may explain the fibrofatty replacement of the myocardium a characteristic pathological finding in ARVC
Abcam Rabbit Anti-Mouse IgG H&L (HRP) preadsorbed.
Rabbit Anti-Mouse IgG H&L (HRP) preadsorbed.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Meckelin Rabbit mAb
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane The gene functions in centriole migration to the apical membrane and formation of the primary cilium Multiple transcript variants encoding different isoforms have been found for this gene Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6)
Cayman Chemical S100BCTerm RabbIt Monclo 100uL
An inhibitor of SIK2 (IC50 50s 21.63 and 6.63 nM respectively) inhibits TNF-a secretion in RAW 264.7 cells (IC50 ~2.5 UM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 UM inhibits growth of 10 ovarian cancer cell lines (IC50s 0.8-2.6 UM) and increases sensitivity of eight of them to paclitaxel halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 UM has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
Cayman Chemical InTRleukIn12R2 RabbIt Mon 50uL
A positive allosteric modulator of AMPA receptors potentiates glutamate-induced currents in HEK293 cells expressing human GluR2 homomeric AMPA receptors (EC50 2.51 UM) as well as HEK293 cells expressing GluR1 GluR3 or GluR4 homomeric AMPA receptors increases novel object exploration in a novel object recognition test in rats at 0.3 and 1 mg/kg reduces escape latencies in the Morris water maze in aged rats
ABclonal Technology FABP5 Rabbit mAb
This gene encodes the fatty acid binding protein found in epidermal cells and was first identified as being upregulated in psoriasis tissue Fatty acid binding proteins are a family of small highly conserved cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands FABPs may play roles in fatty acid uptake transport and metabolism Polymorphisms in this gene are associated with type 2 diabetes The human genome contains many pseudogenes similar to this locus
Cayman Chemical CD33CTerm RabbIt Monclon 100uL
A pyrimidine analog and nitrosourea alkylating agent inhibits the growth of U-251MG and EA285 glioma cells at 10 g/ml increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors at 30 mg/kg
ProteinSimple Anti-Mouse Detection Module, 24 x 25 Caps
Includes 3 Detection Modules. Each Detection Module includes Luminol-S, Peroxide, Antibody Diluent 2, Anti-Mouse Secondary Antibody, Streptavidin-HRP. Sufficient for 600 samples. Store the unopened product at 2 - 8 °C. Do not use past expiration date.
ABclonal Technology HSF1 Rabbit mAb
The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE) This protein plays a role in the regulation of lifespan Expression of this gene is repressed by phosphorylation which promotes binding by heat shock protein 90
Cayman Chemical p70S6KNTerm RabbIt Moncl 100uL
A flavonoid inhibits Cav3 2 and high-voltage-activated calcium currents in whole-cell patch-clamp assays using HEK293 cells (IC50s 0 912 and 4 765 UM respectively) reduces the activity of ALR2 (IC50 6 2 UM for the recombinant human enzyme) inhibits proliferation of PC3 and DU145 prostate cancer cells (IC50s 18 4 and 29 1 UM respectively) reduces mechanical allodynia in a mouse model of neuropathic pain induced by partial sciatic nerve ligation at 20 and 30 mg/kg